American Society of Microbiology ASM-ABMM ABMM

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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A patient with a history of travel to South America presents with fever, lymphadenopathy, and hepatosplenomegaly. Peripheral blood smear reveals the presence of trypomastigotes. The MOST likely diagnosis is:

A) Chagas disease (American trypanosomiasis)
B) African trypanosomiasis (sleeping sickness)
C) Leishmaniasis
D) Malaria

2. Histopathological examination of lung tissue from an immunocompromised patient reveals large (8-15 µm), spherical yeast cells with thick, refractile walls and characteristic single, broad-based budding. These findings are most suggestive of infection with:

A) Coccidioides immitis/posadasii
B) Paracoccidioides brasiliensis
C) Blastomyces dermatitidis
D) Histoplasma capsulatum

3. For epidemiological tracking and outbreak investigations of Clostridioides difficile infection (CDI), which molecular typing method based on PCR amplification targeting repetitive elements within the pathogenicity locus (PaLoc) has historically been widely used and designated by specific nomenclature (e.g., NAP1/BI
/027)?

A) PCR Ribotyping
B) Pulsed-field gel electrophoresis (PFGE)
C) Multilocus sequence typing (MLST)
D) Whole-genome sequencing (WGS) SNP analysis

4. A clinical microbiology laboratory is investigating a cluster of Clostridium difficile infections in a hospital.
Which of the following methods is MOST appropriate for determining if the isolates from different patients are related?

A) Gram staining and morphology
B) Enzyme immunoassay for C. difficile toxins
C) Antimicrobial susceptibility testing
D) Molecular typing (e.g., PCR ribotyping)

5. The azole class of antifungal agents (e.g., fluconazole, voriconazole) exerts its effect primarily by inhibiting which fungal-specific enzyme involved in membrane synthesis?

A) Chitin synthase
B) Beta-(1,3)-glucan synthase
C) Squalene epoxidase
D) Lanosterol 14-alpha-demethylase

Solutions: