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ASCP ASCP-MLT Exam Syllabus Topics:
| Section | Weight | Objectives |
|---|---|---|
| Topic 1: Blood Banking | 15–20% | - Blood group systems and immunology - Transfusion practice and testing - Blood products and components |
| Topic 2: Laboratory Operations | 5–10% | - Quality assessment and safety - Instrumentation and laboratory mathematics |
| Topic 3: Microbiology | 15–20% | - Virology and parasitology testing - Bacteriology and mycology procedures |
| Topic 4: Hematology | 20–25% | - Physiology and disease states - Laboratory testing and hemostasis |
| Topic 5: Urinalysis and Other Body Fluids | 5–10% | - Physical and chemical testing - Microscopic analysis and disease correlation |
| Topic 6: Immunology | 5–10% | - Principles of immunology - Serologic procedures and immune diseases |
| Topic 7: Chemistry | 20–25% | - Carbohydrates, lipids, and enzymes - Electrolytes, acid-base, and toxicology |
ASCP MEDICAL LABORATORY TECHNICIAN - MLT(ASCP) Sample Questions:
Question #1
Though it may not be required, TDM should still be used to confirm adequate dosing. Genotyping does not make TDM redundant.
A PM will metabolize the drug more slowly and therefore will need lower doses. CYP2D6 metabolizes many different drugs; it is not associated with just one class of drugs. Anytime a drug is taken that competes for the same metabolizing enzyme as another drug, there is potential for the concentrations of both drugs to be increased.
A patient has been characterized as a CYP2D6 poor metabolizer (PM) after genotyping. Which of the following statements is not true?
A. The patient is less likely to require therapeutic drug monitoring (TDM) since the genotype is known.
B. CYP2D6 metabolizes many drugs, and so attention must be given to the doses of drugs from different classes.
C. The patient will likely need lower doses of CYP2D6-metabolized drugs.
Question #2
Which specimen should be collected last?
Question options:
A. Clotted specimen
B. Specimen requiring special handling
C. Fasting specimen
D. STAT specimen
Question #3
hs-CRP is a recent marker of chronic inflammation. New measurements of CRP in lower levels (hs-CRP) are now measured to monitor risk of cardiovascular disease.
Select the statement that best describes hs-CRP?
A. hs-CRP is a marker of chronic inflammation and measured to predict the risk of cardiovascular disease
B. hs-CRP is a measurement of acute inflammation and is used to monitor these conditions
C. hs-CRP is an anti-inflammatory adipokine synthesized by adipocytes
D. hs-CRP is decreased in inflammatory conditions and measured to predict a return of inflammation
Question #4
Which area of the laboratory is responsible for blood coagulation studies that test for the patient's ability to clot their blood?
A. Blood banking/transfusion medicine
B. Clinical chemistry
C. Immunology
D. Hematology
Question #5
What are the certification requirements for clinical laboratory professionals?
A. on the job training
B. college degree
C. national certification exam
D. college degree and a national certification exam
Solutions:
| Question #1 Correct Answer: A | Question #2 Correct Answer: D | Question #3 Correct Answer: A | Question #4 Correct Answer: D | Question #5 Correct Answer: D |






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